The conformation of the spike was selected from molecular dynamics simulations performed by Casalino et al. On the left, the full-length SARS-CoV-2 spike in the open state-that is, with one receptor binding domain (RBD) in the “up” conformation-is shown with a cyan transparent surface overlaid on the cartoon representation of its secondary structure.
( Science 369: 330–333 ) and Shajahan et al. N-/O-glycans have been modeled according to Watanabe et al. ( ACS Cent Sci 6: 1722–1734 ) based on the cryo-EM structure by Wrapp et al. The model of the spike has been developed by Casalino et al. Cummingsįront cover artwork: Molecular representation of the full-length, fully glycosylated, all-atom model of the SARS-CoV-2 spike protein in the open state, embedded in the viral membrane. Illustrator and Illustrations Coordinator Richard D. Publisher and Acquisition Editor John InglisĬover Designers Lorenzo Casalino and Rommie Amaro Library of Congress Control Number: 2021950841
This edition includes a broader focus on all lineages of life-forms a wider range of topics, from biology and medicine to chemistry, bioenergy, and materials science a more diverse and international group of contributing authors with expertise in specific areas further expansion of the monosaccharide symbol nomenclature for representation of glycans and a greater attention to informatics, with relevance to exploring the glycome in relation to the genome, transcriptome, proteome, lipidome, and metabolome. The fourth edition of this primary textbook in the field continues in the prior tradition to provide a basic overview of Glycobiology, directed toward the advanced undergraduate or the beginning graduate-level student of molecular and cellular biology and biomedicine. The field includes the chemistry of carbohydrates, the enzymology of glycan formation and degradation, the recognition of glycans by specific proteins, roles of glycans in complex biological systems, and glycan analysis or manipulation by various techniques. Glycobiology is a rapidly growing field in the natural sciences, with broad relevance to many areas of basic research, biomedicine, and biotechnology. Glycobiology is the study of the structure, biosynthesis, biology, and evolution of saccharides (sugar chains or glycans) that are widely distributed in nature, in all life-forms.
0 kommentar(er)
